Evaluating the hypolipidemic effect of garlic essential oil encapsulated in a novel double-layer delivery system

文献类型： 外文期刊

第一作者： Zhang, Xueli

作者： Zhang, Xueli;Tang, Xiaozhen;Zhang, Xueli;Guo, Xu;Sun, Jinyue;Chen, Yingying;Zhang, Mengqi;Wang, Wenliang;Liu, Chao;Li, Ningyang;Simal-Gandara, Jesus;Xu, Huiying

作者机构：

关键词： Garlic essential oil; Cyclodextrin inclusion complex liposome; delivery system; Characterization; Stability; Lowering blood lipid

期刊名称：COLLOIDS AND SURFACES B-BIOINTERFACES （ 影响因子：5.8； 五年影响因子：5.4 ）

ISSN： 0927-7765

年卷期： 2024 年 237 卷

页码：

收录情况： SCI

摘要： The limited application of garlic essential oil (GEO) is attributed to its pungent taste, poor water solubility and low bioavailability. Liposomes are nontoxic, biodegradable and biocompatible, and beta -cyclodextrin can inhibit undesirable odors and improve the stability and bioavailability. Thus a promising dual -layer GEO beta -cyclodextrin inclusion compound liposome (GEO-DCL) delivery system with both advantages was designed and prepared in this study. Experimental results indicated that the encapsulation efficiency of GEO-DCLs was 5% higher than that of GEO liposomes (GEO-CLs), reaching more than 88%. In vitro release experiment showed that the release rate of GEO in GEO-DCLs was 40% lower than that of GEO-CLs after incubation in gastric juice for 6-h, indicating that the stability of GEO-DCLs was better than GEO-CLs. Evaluation of the effects of GEO-DCLs on lowering blood lipid levels in hypercholesterolemia mice. GEO-DCLs could reduce the weight and fat deposition in hypercholesterolemia mice. Inhibiting the increase of TC, LDL-C, and decrease of HDL-C in mice. The degree of liver injury was decreased, the number of round lipid droplets in liver cytoplasm was reduced, and the growth of fat cells was inhibited. The lipid -lowering effects of GEO-DCLs were dose -dependent. GEO-DCL can improve the bioavailability of GEO and improve dyslipidemia. Based on GEO ' s efficacy in lowering blood lipids, this study developed a kind of GEO-DCL compound pomegranate juice beverage with good taste, miscibility and double effect of reducing blood lipids. This study lays a foundation for the application of GEO in the field of functional food.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序