Autophagy promotes p72 degradation and capsid disassembly during the early phase of African swine fever virus infection

文献类型： 外文期刊

第一作者： Song, Jie

作者： Song, Jie;Li, Jiangnan;Li, Shuai;Zhao, Gaihong;Li, Tingting;Chen, Xin;Liu, Jia;Lai, Xinyu;Liu, Sitong;Zhou, Qiongqiong;Huang, Li;Weng, Changjiang;Li, Jiangnan;Li, Tingting;Huang, Li;Weng, Changjiang;Hu, Boli

作者机构：

关键词： African swine fever virus; p72; selective autophagy; Stub1; HSPA8; capsid disassembly

期刊名称：JOURNAL OF VIROLOGY （ 影响因子：3.8； 五年影响因子：3.9 ）

ISSN： 0022-538X

年卷期： 2025 年 99 卷 1 期

页码：

收录情况： SCI

摘要： During viral infections, autophagy functions as a cell-intrinsic defense mechanism by facilitating the delivery of virions or viral components to the endo somal/lysosomal pathway for degradation. In this study, we report that internalized African swine fever virus (ASFV) virions enter autolysosomes during the early phase of viral infection. Autophagy selectively targets the major capsid protein p72 within the ASFV virion. The ASFV p72 protein undergoes modification through ubiquitination at the C-terminus, a process mediated by the E3 ubiquitin ligase Stub1. Subsequently, ubiquitinated p72 is recognized by the autophagy receptor SQSTM1/p62 through its ubiquitin-binding domain. Stub1 facilitates the ubiquitination and degradation of p72 in an HSPA8-dependent manner via selective autophagy. Autophagy plays a critical role in disassembling ASFV virions and further promotes the release of ASFV genomic DNA. These findings support the notion that autophagy is involved in and contributes to the capsid disassembly of ASFV, providing valuable insights into this essential viral process.

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