Discovery of Antibacterial Azaphilone Hybrid Metabolites from Marine-Derived Aspergillus terreus PPS1

文献类型： 外文期刊

第一作者： Zheng, Yao-Yao

作者： Zheng, Yao-Yao;Zhang, Ya-Hui;Liu, Zhiqing;Wang, Pingyuan;Wang, Chang-Yun;Zheng, Yao-Yao;Zhang, Ya-Hui;Liu, Zhiqing;Wang, Pingyuan;Wang, Chang-Yun;Zheng, Yao-Yao;Zheng, Yao-Yao;Zhang, Ya-Hui;Liu, Zhiqing;Wang, Pingyuan;Wang, Chang-Yun;Zhang, Xiu;Zhang, Meng-Qi;Yao, Guang-Shan

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）

ISSN： 0163-3864

年卷期： 2025 年 88 卷 5 期

页码：

收录情况： SCI

摘要： Three novel azaphilone hybrids (1-3) with two types of structural units, along with four known compounds (4-7), were obtained from the marine sediment-derived fungus Aspergillus terreus PPS1. Asperbenzophilone A (1) features an unprecedented 6/6/6/6 ring system containing a hemiketal group. Butyropyranones I and II (2 and 3) are equipped with an azaphilone fragment preasperpyranone and a butyrolactone, which are connected through ether bonds. Comprehensive spectroscopic techniques, ECD calculations, and deduction of biosynthetic pathways were used to confirm the planar structures and absolute configurations of the new compounds. Compound 2 displayed significant anti-MRSA activity. Additionally, compound 2 exhibited moderate cytotoxic activity on human tumor cell lines 786-O, 5637, MCF-7, A-673, and 293T and medium inhibitory activity against the SARS-CoV-2 main protease (Mpro/3CLpro).

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