The emergence of Dengue Fever in Sheikhupura, Pakistan: its seroprevalence and risk factors assessment during 2014-2017

文献类型： 外文期刊

第一作者： Mukhtar, Muhammad Uzair

作者： Mukhtar, Muhammad Uzair;Iqbal, Naveed;Mukhtar, Maria;Nawaz, Zeeshan;Bhatti, Adil;Haq, Fatima;Arslan, Ali;Rashid, Muhammad

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关键词： Dengue; prevalence; IgM; IgG; Pakistan

期刊名称：JOURNAL OF INFECTION IN DEVELOPING COUNTRIES （ 影响因子：0.968； 五年影响因子：1.484 ）

ISSN： 1972-2680

年卷期： 2021 年 15 卷 9 期

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收录情况： SCI

摘要： Introduction: District Sheikhupura encountered its first dengue outbreak in 2014 but lacked serological evidence and reports of risk factors associated with it. To assess this, a hospital-based study was conducted from January 2014 to December 2017. Methodology: Blood from 333 participants was collected, the serum obtained was tested for IgG and IgM antibodies against DENV using a commercially available ELISA kit. Results: The results showed that out of all (n= 333) samples tested, 120 were turned up positive for DENV, making an overall prevalence of 36%. Of the 120 confirmed cases, 55% (n = 66) were recorded in 2014, 10% (n = 12) in 2015, 27.5% (n = 33) in 2016, and 7.5% (n = 9) in 2017. It was found that 68.3% (n = 82) were male and 31.7% (n = 38) were female, with 61% (n = 74) patients aged between 11-30 years. The highest prevalence of infection, 94.2% (n = 113), was noted after the rainy season. During the study, the highest number of cases appeared in Ferozewala Tehsil. The factors age, gender, and season were found statistically significant with the prevalence of infection (p < 0.05). Conclusions: The study is the first report on the detection of dengue in the Sheikhupura district. The survey anticipated its geographical expansion, determined associated risk factors, and suggests active disease surveillance in the area.

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