Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes

文献类型： 外文期刊

第一作者： Tang, Shou-Bin

作者： Tang, Shou-Bin;Zhang, Ting-Ting;Yin, Shen;Shen, Wei;Ge, Zhao-Jia;Zhang, Ting-Ting;Zhang, Cui-Lian;Luo, Shi-Ming;Sun, Qing-Yuan;Luo, Shi-Ming;Sun, Qing-Yuan;Zhao, Yong;Klinger, Francesca Gioia

作者机构：

关键词： Oocytes; methylation; Undernourishment in utero; Metabolic disorders; Transgenerational transmission

期刊名称：BMC BIOLOGY （ 影响因子：5.4； 五年影响因子：7.1 ）

ISSN：

年卷期： 2023 年 21 卷 1 期

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收录情况： SCI

摘要： BackgroundUndernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we found that undernourishment in utero resulted in metabolic disorders of female F1 and F2 in mouse model.ResultsUndernutrition in utero induced metabolic disorders of F1 females, which was transmitted to F2 females. The global methylation in oocytes of F1 exposed to undernutrition in utero was decreased compared with the control. KEGG analysis showed that genes with differential methylation regions (DMRs) in promoters were significantly enriched in metabolic pathways. The altered methylation of some DMRs in F1 oocytes located at the promoters of metabolic-related genes were partially observed in F2 tissues, and the expressions of these genes were also changed. Meanwhile, the abnormal DNA methylation of the validated DMRs in F1 oocytes was also observed in F2 oocytes.ConclusionsThese results indicate that DNA methylation may mediate the transgenerational inheritance of metabolic disorders induced by undernourishment in utero via female germline.

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