Simultaneous separation and detection chiral fenobucarb enantiomers using UPLC-MS/MS

文献类型： 外文期刊

第一作者： Xia, Weitong

作者： Xia, Weitong;He, Zongzhe;Hu, Kunming;Gao, Beibei;Zhang, Zhaoxian;Wang, Minghua;Wang, Qiang;Wang, Qiang

作者机构：

关键词： Fenobucarb enantiomers; Enantioseparation; Absolute configuration; Stereoselective degradation

期刊名称：SN APPLIED SCIENCES （ 影响因子：2.6； 五年影响因子：2.6 ）

ISSN： 2523-3963

年卷期： 2019 年 1 卷 7 期

页码：

收录情况： SCI

摘要： A reliable and sensitive method was developed and validated for the determination of chiral pesticide fenobucarb enantiomers with UPLC-MS/MS. The fenobucarb enantiomers were baseline separated on Daicel IG-3 chiral column using a mixture of acetonitrile and 0.1% formic acid water (60:40, v/v) as mobile phase. The absolute configuration of fenobucarb enantiomers was confirmed as (R)-(+)-fenobucarb and (S)-(-)-fenobucarb by experimental and calculated electronic circular dichroism spectra. Good linearity (R-2 > 0.9962) was obtained for the four matrix calibration curves within the range of 0.5-50 mu g mL(-1). The limit of detection of the two enantiomers were in the range of 0.07-0.16 mu g L-1. The mean recoveries of the two enantiomers ranged from 80.4 to 102% with intra-day relative standard deviations (RSDs) from 1.8 to 6.6% and inter-day RSDs from 3.0 to 5.7% in four matrices. The (R)-(+)-fenobucarb degraded faster than (S)-(-)-isomer in cucumber. The established-method can provide additional information for the further research about the enantioselective environmental behaviors of fenobucarb.

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