Regulation of nitrogen starvation responses by the alarmone (p)ppGpp in rice

文献类型： 外文期刊

第一作者： Li, Hanwen

作者： Li, Hanwen;Nian, Jinqiang;Fang, Shuang;Guo, Meng;Zhang, Fengxia;Wang, Qing;Zhang, Jian;Bai, Jiaoteng;Xin, Peiyong;Wang, Guodong;Zuo, Jianru;Chu, Jinfang;Ma, Xiaohui;Li, Hanwen;Nian, Jinqiang;Chen, Fan;Wang, Guodong;Wang, Yingchun;Zuo, Jianru;Chu, Jinfang;Ma, Xiaohui;Huang, Xiahe;Chen, Fan;Wang, Yingchun;Zhang, Fengxia;Wang, Qing;Chen, Fan;Wang, Guodong;Zuo, Jianru;Dong, Guojun;Qian, Qian;Xie, Xianzhi;Chen, Fan;Zuo, Jianru;Zuo, Jianru

作者机构：

关键词： Rice; Stringent response; Nitrogen starvation response; (p)ppGpp; ARE2

期刊名称：JOURNAL OF GENETICS AND GENOMICS （ 影响因子：5.723； 五年影响因子：5.755 ）

ISSN： 1673-8527

年卷期： 2022 年 49 卷 5 期

页码：

收录情况： SCI

摘要： Nitrogen is an essential macronutrient for all living organisms and is critical for crop productivity and quality. In higher plants, inorganic nitrogen is absorbed through roots and then assimilated into amino acids by the highly conserved glutamine synthetase/glutamine:2-oxoglutarate aminotransferase (GS/GOGAT) cycle. How nitrogen metabolism and nitrogen starvation responses of plants are regulated remains largely unknown. Previous studies revealed that mutations in the rice ABNORMAL CYTOKININ RESPONSE1 (ABC1) gene encoding Fd-GOGAT cause a typical nitrogen deficiency syndrome. Here, we show that ARE2 (for ABC1 REPRESSOR2) is a key regulator of nitrogen starvation responses in rice. The are2 mutations partially rescue the nitrogen-deficient phenotype of abc1 and the are2 mutants show enhanced tolerance to nitrogen deficiency, suggesting that ARE2 genetically interacts with ABC1/Fd-GOGAT. ARE2 encodes a chloroplast-localized RelA/SpoT homolog protein that catalyzes the hydrolysis of guanosine pentaphosphate or tetraphosphate (p)ppGpp, an alarmone regulating the stringent response in bacteria under nutritional stress conditions. The are2 mutants accumulate excessive amounts of (p)ppGpp, which correlate with lower levels of photosynthetic proteins and higher amino acid levels. Collectively, these observations suggest that the alarmone (p)ppGpp mediates nitrogen stress responses and may constitute a highly conserved mechanism from bacteria to plants. Copyright (C) 2022, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

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