Insights into the combined toxicity and mechanisms of BDE-47 and PFOA in marine blue mussel: An integrated study at the physiochemical and molecular levels

文献类型： 外文期刊

第一作者： Geng, Qianqian

作者： Geng, Qianqian;Zou, Liang;Guo, Mengmeng;Peng, Jixing;Li, Fengling;Bi, Yujie;Jiang, Shuqi;Qin, Hanlin;Tan, Zhijun;Geng, Qianqian;Zou, Liang;Tan, Zhijun

作者机构：

关键词： Emerging pollutants; Combined pollution; Marine shellfish; Transcriptomic; Metabolomics

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.1； 五年影响因子：4.4 ）

ISSN： 0166-445X

年卷期： 2024 年 273 卷

页码：

收录情况： SCI

摘要： The coexistence of multiple emerging contaminants imposes a substantial burden on the ecophysiological functions in organisms. The combined toxicity and underlying mechanism requires in-depth understanding. Here, marine blue mussel (Mytilus galloprovincialis L.) was selected and exposed to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE-47) and perfluorooctanoic acid (PFOA) individually and in combination at environmental related concentrations to elucidate differences in stress responses and potential toxicological mechanisms. Characterization and comparison of accumulation, biomarkers, histopathology, transcriptomics and metabolomics were performed. Co-exposure resulted in differential accumulation patterns, exacerbated histopathological alterations, and different responses in oxidative stress and biomarkers for xenobiotic transportation. Moreover, the identified differentially expressed genes (DEGs) and differential metabolites (DEMs) in mussels were found to be annotated to different metabolic pathways. Correlation analyses further indicated that DEGs and DEMs were significantly correlated with the above biomarkers. BDE-47 and PFOA altered the genes and metabolites related to amino acid metabolism, energy and purine metabolism, ABC transporters, and glutathione metabolism to varying degrees, subsequently inducing accumulation differences and combined toxicity. Furthermore, the present work highlighted the pivotal role of Nrf2-keap1 detoxification pathway in the acclimation of M. galloprovincialis to reactive oxygen species (ROS) stress induced by BDE-47 and PFOA. This study enabled more comprehensive understanding of combined toxic mechanism of multi emerging contaminants pollution.

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