The Effect of Sow Maternal Behavior on the Growth of Piglets and a Genome-Wide Association Study

文献类型： 外文期刊

第一作者： Liu, Xin

作者： Liu, Xin;Li, Hanmei;Wang, Ligang;Zhang, Longchao;Wang, Lixian

作者机构：

关键词： maternal behavior; piglet growth; comparative analysis; GWAS

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2023 年 13 卷 24 期

页码：

收录情况： SCI

摘要： Simple Summary Sows' maternal behavior is important for piglet survival and growth. It is critical to explore their genetic mechanisms for better breeding. Comparative analysis showed that piglets' growth traits were strongly associated with sows' maternal behaviors. Through a genome-wide association study (GWAS) for biting piglets (BP), crushing piglets (CP), trampling piglets (TP) and screaming test (ST) traits, several candidate genes and single nucleotide polymorphisms (SNPs) were found. These findings preliminarily elucidate the genetic basis of sows' maternal behavior traits and provide markers for molecular breeding.Abstract Sows' maternal behavior is important for improving piglet survival and growth; thus, breeding for good mothering sows is necessary for pig production. However, there is little research on the genetic mechanism of maternal behavior. In this study, a comparative analysis of piglets' growth traits between good and bad maternal behavior groups and a genome-wide association study (GWAS) was performed to elucidate the impact of sows' maternal behavior on piglet growth and identify candidate genes and markers of sow's maternal behaviors. Comparing the growth traits of piglets between good and bad sows' maternal behavior groups, the results showed that the growth traits of piglets from sows with good maternal behavior were better than those from sows with bad maternal behavior and especially for the multiparous sows group, this comparative difference was significant. For the intensive study of the genetic mechanisms of sows' maternal behavior, a total of 452 sows were genotyped using the Illumina Porcine 50K SNP Chip, and 4 traits, including biting piglets (BP), crushing piglets (CP), trampling piglets (TP) and screaming test (ST), were examined. Using a GWAS, 20 single nucleotide polymorphisms (SNPs) were found to be associated with these traits. Within 1 Mb upstream and downstream of the significant SNPs screened, 138 genes were obtained. After pathway enrichment and gene annotation, HIP1, FZD9 and HTR7 were identified as important candidate genes affecting sows' maternal behaviors. These findings preliminarily elucidate the genetic basis of sows' maternal behavior traits and provide candidate genes and markers for molecular breeding in pigs.

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