Benzylphenethylamine Alkaloids from Hosta plantaginea with Inhibitory Activity against Tobacco Mosaic Virus and Acetylcholinesterase

文献类型： 外文期刊

第一作者： Wang, Yue-Hu

作者： Wang, Yue-Hu;Zhang, Zhong-Kai;Yang, Fu-Mei;Sun, Qian-Yun;He, Hong-Ping;Di, Ying-Tong;Mu, Shu-Zhen;Lu, Yang;Chang, Ying;Zheng, Qi-Tai;Ding, Ming;Dong, Jia-Hong;Hao, Xiao-Jiang

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

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年卷期：

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收录情况： SCI

摘要： Five new benzylphenethylamine alkaloids,hostasine(1),8-demethoxyhostasine,8-demethoxy-10-O-methylhostasine,10-O-methylhostasine,and 9-O-demethyl-7-O-methyllycorenine,along with 12 known compounds,were isolated from Hosta plantaginea by bioassay-guided fractionation.The structures of the new alkaloids were established by means of extensive spectroscopic methods,and the relative configuration of 1 was further confirmed by single-crystal X-ray diffraction.7-Deoxy-trans-dihydronarciclasine(IC_(50)= 1.80 mu M),a known alkaloid,showed strong activity against tobacco mosaic virus by the half-leaf method.Some of these alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase.8-Demethoxy-10-O-methylhostasine was found to possess significant activity,with an IC_(50)of 2.32 mu M.

分类号： R28

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