Resveratrol-loaded sulfated Hericium erinaceus p-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects

文献类型： 外文期刊

第一作者： Zhang, Zhong

作者： Zhang, Zhong;Wu, Di;Li, Wen;Chen, Wanchao;Liu, Peng;Yang, Yan;Ge, Meili;Zhang, Haiyun

作者机构：

关键词： Resveratrol; Sulfated Hericium erinaceus p-glucan; Nanoparticles; Anti-inflammatory activity; Synergistic effect

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：11.2； 五年影响因子：10.2 ）

ISSN： 0144-8617

年卷期： 2024 年 332 卷

页码：

收录情况： SCI

摘要： Resveratrol (RES) is a natural polyphenol with excellent biological activity. But the poor stability and bioavailability of RES severely limit its application. Thus, the resveratrol-loaded sulfated Hericium erinaceus p-glucan-chitosan nanoparticles (DS-CS-RES NPs) were prepared using electrostatic self-assembly to solve these problems in this study. The structure of DS-CS-RES NPs was spherical or sub spherical shape with small average particle size (191.07 nm), which was characterized by FT-IR, FS, XRD and TEM. DS-CS-RES NPs exhibited good stability and RES had a sustainable release from the nanoparticles in gastrointestinal digestion. Meanwhile, DSCS-RES NPs could improve the inflammatory injury of LPS stimulated RAW264.7 macrophages by inhibiting the production of NO, IL -1p, IL -6 and TNF-a. Furthermore, DS-CS-RES NPs had strong anti-inflammatory activity by regulating protein levels of NF-xB p65, STAT1 and TLR4 through NF-xB and JAK-STAT1 signaling pathway in vitro, and sulfated H. erinaceus p-glucan-chitosan nanoparticle (DS-CS NPs) and RES had synergistic antiinflammatory effect. Overall, DS-CS NPs can serve as a potential green and safe functional carrier for encapsulating resveratrol, which can improve its anti-inflammatory activity. This work may be conducive to the development of functional carrier for encapsulating RES and applications of hydrophobic active molecules in functional foods or medicines.

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