The multi-kingdom microbiome of the goat gastrointestinal tract

文献类型： 外文期刊

第一作者： Cao, Yanhong

作者： Cao, Yanhong;Huang, Kongwei;Cui, Kuiqing;Li, Ying;Liu, Qingyou;Cao, Yanhong;Feng, Tong;Wu, Yingjian;Wang, Teng;Gao, Na L.;Chen, Wei-Hua;Feng, Tong;Xu, Yixue;Luo, Yuhong;Wang, Yan;Li, Zhipeng;Wang, Xiaobo;Cui, Kuiqing;Rehman, Saif ur;Liu, Qingyou;Du, Li;Xiao, Qian;Xuan, Zeyi;Chen, Shaomei;Yao, Na;Tang, Xiangfang;Liu, Dewu;Han, Hongbing;Chen, Wei-Hua

作者机构：

关键词： Goat; Gastrointestinal tract; Microbiome; Metagenome-assembled genomes; Bacteriome; Archaeome; Virome; Bacteriophages; Plant fiber digestion; Methane production

期刊名称：MICROBIOME （ 影响因子：15.5； 五年影响因子：19.4 ）

ISSN： 2049-2618

年卷期： 2023 年 11 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundGoat is an important livestock worldwide, which plays an indispensable role in human life by providing meat, milk, fiber, and pelts. Despite recent significant advances in microbiome studies, a comprehensive survey on the goat microbiomes covering gastrointestinal tract (GIT) sites, developmental stages, feeding styles, and geographical factors is still unavailable. Here, we surveyed its multi-kingdom microbial communities using 497 samples from ten sites along the goat GIT.ResultsWe reconstructed a goat multi-kingdom microbiome catalog (GMMC) including 4004 bacterial, 71 archaeal, and 7204 viral genomes and annotated over 4,817,256 non-redundant protein-coding genes. We revealed patterns of feeding-driven microbial community dynamics along the goat GIT sites which were likely associated with gastrointestinal food digestion and absorption capabilities and disease risks, and identified an abundance of large intestine-enriched genera involved in plant fiber digestion. We quantified the effects of various factors affecting the distribution and abundance of methane-producing microbes including the GIT site, age, feeding style, and geography, and identified 68 virulent viruses targeting the methane producers via a comprehensive virus-bacterium/archaea interaction network.ConclusionsTogether, our GMMC catalog provides functional insights of the goat GIT microbiota through microbiome-host interactions and paves the way to microbial interventions for better goat and eco-environmental qualities.-Pdb_6YZpzy_mmd53S_tihVideo AbstractConclusionsTogether, our GMMC catalog provides functional insights of the goat GIT microbiota through microbiome-host interactions and paves the way to microbial interventions for better goat and eco-environmental qualities.-Pdb_6YZpzy_mmd53S_tihVideo Abstract

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