Promising advancement in fermentative succinic acid production by yeast hosts

文献类型： 外文期刊

第一作者： Li, Chong

作者： Li, Chong;Sang, Zhenyu;Yan, Jianbin;Ong, Khai Lun;Li, Xiaotong;Patria, Raffel Dharma;Lin, Carol Sze Ki;Cui, Zhiyong;Qi Qingsheng;Sang, Zhenyu;Fickers, Patrick

作者机构：

关键词： Engineering strategies; Key producers; Renewable resources; Saccharomyces cerevisiae; Yarrowia lipolytica

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2021 年 401 卷

页码：

收录情况： SCI

摘要： As a platform chemical with various applications, succinic acid (SA) is currently produced by petrochemical processing from oil-derived substrates such as maleic acid. In order to replace the environmental unsustainable hydrocarbon economy with a renewable environmentally sound carbohydrate economy, bio-based SA production process has been developed during the past two decades. In this review, recent advances in the valorization of solid organic wastes including mixed food waste, agricultural waste and textile waste for efficient, green and sustainable SA production have been reviewed. Firstly, the application, market and key global players of bio-SA are summarized. Then achievements in SA production by several promising yeasts including Saccharomyces cerevisiae and Yarrowia lipolytica are detailed, followed by calculation and comparison of SA production costs between oil-based substrates and raw materials. Lastly, challenges in engineered microorganisms and fermentation processes are presented together with perspectives on the development of robust yeast SA producers via genome-scale metabolic optimization and application of low-cost raw materials as fermentation substrates. This review provides valuable insights for identifying useful directions for future bio-SA production improvement.

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