Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo

文献类型： 外文期刊

第一作者： Qian, Jing

作者： Qian, Jing;Wang, Jiemin;Cao, Ting;Zheng, Lei;Cao, Yuping;Qin, Wenwu;Qian, Jing;Wang, Jiemin;Cao, Ting;Zheng, Lei;Cao, Yuping;Qin, Wenwu;Zhang, Liang;Liu, Yun;Teng, Zhidong;Guo, Huichen;Teng, Zhidong;Guo, Huichen

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关键词： Vanin-1; Red emission; Imaging in vivo; Starvation-induced; Diabetes

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2021 年 401 卷

页码：

收录情况： SCI

摘要： Pantetheinase, also known as Vanin-1, catalyzes pantetheine to decompose into the precursor of CoA - pantothenic acid and aminothiol cysteamine. Studies have shown that Vanin-1 plays an important role in many important physiological pathologies. In this paper, a new red emission ratio fluorescent probe DCM-PA (I-640 nm/I-564 run) has been implemented to detect the activity of Vanin-1 in cells and vivo. DCM-PA has short response time (30 min), high selectivity and low sensitivity (DL =0.69 ng/mL). Also, we have applied DCM-PA for imaging in cells and mice, and the results have indicated that the probe has a non-negligible potential for monitoring the activity of Vanin-1 in situ, benefiting further to study the role of Vanin-1 in physiology and pathology. In addition, the up-regulation of this enzyme by starvation confirmed the inevitable connection between diabetes and abnormal expression of Vanin-1.

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