N-Ethyl-2-Pyrrolidinone-Substituted Flavan-3-Ols with Anti-inflammatory Activity in Lipopolysaccharide-Stimulated Macrophages Are Storage-Related Marker Compounds for Green Tea

文献类型： 外文期刊

第一作者： Dai, Weidong

作者： Dai, Weidong;Xie, Dongchao;Wu, Wenliang;Peng, Jiakun;Lin, Zhi;Lou, Ni;Song, Huiyi;Shang, Dong;Yin, Peiyuan;Lou, Ni;Song, Huiyi;Shang, Dong;Yin, Peiyuan;Hu, Zhengyan;Lu, Meiling

作者机构：

关键词： green tea; storage; EPSF; anti-inflammation; NF-kappa B signaling pathway; metabolomics

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2020 年 68 卷 43 期

页码：

收录情况： SCI

摘要： Fresh green tea (GT) is commonly considered to have better sensory flavor and higher commercial value than longterm-stored GT; however, the chemical variations during storage are unclear. In this study, the chemical profiles of stored GT were surveyed among time-series samples from 0 to 19 months using a nontargeted metabolomics method. Seven N-ethyl-2-pyrrolidinone-substituted flavan-3-ols (EPSFs) increased from 0.022 +/- 0.019 to 3.212 +/- 0.057 mg/g within 19 months (correlation coefficients with storage duration ranging from 0.936 to 0.965), and they were the most significantly increased compounds among the 127 identified compounds. Two representative EPSFs (R-EGCG-cThea and S-EGCG-cThea) possess potential anti-inflammatory properties by suppressing the expression, phosphorylation, and nuclear translocation of nuclear factor kappa-B (NF-kappa B) p65 in lipopolysaccharide-stimulated macrophages based on western blotting and immunofluorescence results. In conclusion, EPSFs were found to be marker compounds for stored GT and showed potential anti-inflammatory activity by regulating the NF-kappa B signaling pathway.

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