Effects of supplementation with beta-carotene on the growth performance and intestinal mucosal barriers in layer-type cockerels

文献类型： 外文期刊

第一作者： Hui, Junnan

作者： Hui, Junnan;Li, Lingxi;Li, Ruonan;Wu, Min;Yang, Yu;Zheng, Xin;Wang, Jinghui;Fan, Yuanyuan

作者机构：

关键词： Hyline Brown chicks; intestinal barriers; intestinal microbiota; RA-mediated pathway; beta-carotene

期刊名称：ANIMAL SCIENCE JOURNAL （ 影响因子：1.749； 五年影响因子：1.909 ）

ISSN： 1344-3941

年卷期： 2020 年 91 卷 1 期

页码：

收录情况： SCI

摘要： beta-carotene is a robust modulator of mucosal barriers, and it can amplify the immunoglobulin A (IgA) response via the retinoic acid (RA)-mediated pathway. We investigated the influence of beta-carotene on intestinal barriers in layer-type cockerels. In this study, beta-carotene has a positive influence on growth performance and intestinal morphology. beta-carotene remarkably enhanced serum secretory immunoglobulin A (sIgA) levels, jejunal mucosal sIgA, and IgA concentrations. beta-Carotene significantly enhanced mRNA expression levels of IgA, CC chemokine receptor-9 (CCR9), polymeric immunoglobulin receptor (pIgR), and retinoic acid receptor alpha (RAR alpha) in the ileal tissues and pIgR in the jejunal tissues. beta-Carotene improves mRNA expression of intestinal barrier-related proteins including: mucin-2 (MUC-2), zonula occludens-2 (ZO2), occludins (OCLN), and zonula occludens-1 (ZO-1) in the ileal tissues. Moreover, beta-carotene decreased the levels of Escherichia coli and elevates the levels of Lactobacillus. The results indicate that beta-carotene can promote growth performance and contribute to the gradual development of intestinal barriers in Hyline Brown chicks. This study enriches our knowledge about the effects of beta- carotene on intestinal barrier and highlights a theoretical basis of beta-carotene application in the poultry industry.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序