The Pharmacokinetics of Doxycycline in Channel Catfish (Ictalurus punctatus) Following Intravenous and Oral Administrations

文献类型： 外文期刊

第一作者： Xu, Ning

作者： Xu, Ning;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Yang, Yibin;Zhou, Shun;Ai, Xiaohui;Xu, Ning;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Yang, Yibin;Zhou, Shun;Ai, Xiaohui;Xu, Ning;Cheng, Bo;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Yang, Yibin;Zhou, Shun;Song, Yi;Ai, Xiaohui;Fu, Yu;Cheng, Bo;Song, Yi

作者机构：

关键词： doxycycline; channel catfish; bioavailability; pharmacokinetics; non-compartmental model

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.412； 五年影响因子：3.588 ）

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年卷期： 2020 年 7 卷

页码：

收录情况： SCI

摘要： The objective of this study was to investigate the bioavailability (BA) and pharmacokinetics (PK) of doxycycline (DC) in channel catfish (Ictalurus punctatus) following a single intravenous injection at 5 mg/kg and a single oral administration at 50 mg/kg at 24 degrees C. The calculation of PK parameters was based on the software 3P97. The plasma samples were determined using ultra-performance liquid chromatography. Following oral administration, the multiple-peak phenomenon presented in concentration vs. time curve of DC at 2 h (107.01 mg/L), 8 h (55.07 mg/L), and 72 h (15.10 mg/L), respectively. The compartmental model cannot simulate the oral concentration vs. time profile beside a non-compartmental model. The calculated parameters of the elimination rate constant (lambda(z)), the elimination half-life (t(1/2 lambda z)), and the area under the concentration vs. time curve (AUC(0-144)) were 0.037 1/h, 18.91 h, and 2255.45 mu g.h/mL, respectively. After intravenous administration, the concentration vs. time profile of DC was best described by a two-compartmental open model without absorption. The parameters of the distribution rate constant (alpha), the distribution half-life (t(1/2 alpha)), the elimination rate constant (beta), the elimination half-life (t(1/2 beta)), the apparent distribution volume at steady state (V-ss), the total clearance (Cl) and the area under the concentration vs. time curve (AUC(0-infinity)) were 2.79 1/h, 0.25 h, 0.042 1/h, 16.51 h, 300.00 mL/kg, 14.00 mL/h/kg, and 364.99 mu g.h/mL, respectively. For the calculation of BA values at the same condition, the data obtained from intravenous injection were also iterated based on a non-compartmental model, and the corresponding parameters of lambda(z), t(1/2 lambda z), V-z, Cl, and AUC(0-144) were 0.019 1/h, 36.26 h, 480.00 mL/kg, 9.10 mL/h/kg, and 514.45 mu g.h/mL, respectively. However, there was a considerable difference in the same parameter when calculated by compartmental and non-compartmental approaches. Finally, the medium BA value of DC was evaluated to be 43.84%. This study provides future studies with a framework for determining the BA of DC in the development of a new formulation and provides information on the appropriate use of DC in aquaculture.

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