Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401

文献类型： 外文期刊

第一作者： Dai, Yu

作者： Dai, Yu;Li, Kunlong;She, Jianglian;Liao, Shengrong;Lin, Xiuping;Yang, Bin;Wang, Junfeng;Zhou, Xuefeng;Liu, Yonghong;Li, Kunlong;Liao, Shengrong;Lin, Xiuping;Yang, Bin;Wang, Junfeng;Zhou, Xuefeng;Liu, Yonghong;Zeng, Yanbo;Wang, Hao;Dai, Haofu;Tao, Huaming;Liu, Yonghong

作者机构：

关键词： lipopeptides; phthalide; Cochliobolus lunatus; absolute configurations; AChE inhibitory

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN：

年卷期： 2020 年 18 卷 11 期

页码：

收录情况： SCI

摘要： A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.

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