Resveratrol: Evidence for Its Nephroprotective Effect in Diabetic Nephropathy

文献类型： 外文期刊

第一作者： Gowd, Vemana

作者： Gowd, Vemana;Kang, Qingzheng;Wang, Qi;Chen, Feng;Cheng, Ka-Wing;Gowd, Vemana;Kang, Qingzheng;Gowd, Vemana;Kang, Qingzheng;Wang, Qi;Chen, Feng;Cheng, Ka-Wing;Wang, Qi;Wang, Qiang

作者机构：

关键词： polyphenols; diabetes mellitus; diabetic nephropathy; oxidative stress; AMPK; autophagy

期刊名称：ADVANCES IN NUTRITION （ 影响因子：8.701； 五年影响因子：11.584 ）

ISSN： 2161-8313

年卷期： 2020 年 11 卷 6 期

页码：

收录情况： SCI

摘要： Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Dietary habits play a major role in determining the onset and progression of DM-related disorders and a proper diet (rich in fruits and vegetables) can delay or prevent the process of DM pathogenesis. Thus, increasing attention has been paid to polyphenols and polyphenol-rich foods since their increased intake has been associated with a reduced incidence of DM and its associated complications. Resveratrol is a polyphenolic phytoalexin that is mainly found in grapevines and berries. It is available in various pharmaceutical dosages and is widely recommended as a dietary supplement due to its beneficial effects. Remarkably, resveratrol's capability to effectively lower blood glucose levels without any side effects has been amply demonstrated in many in vitro and in vivo studies. Herein, we comprehensively review and discuss the nephroprotective effect of resveratrol during DN and its associated mechanisms. Resveratrol exerts its nephroprotective effects via various mechanisms including reducing oxidative stress and advanced glycation end-product (AGE) production, stimulating autophagy, inhibiting endoplasmic reticulum (ER) stress and inflammation, ameliorating lipotoxicity, activating the AMP kinase (AMPK) pathway, and modulating angiogenesis. Moreover, the use of resveratrol as an adjuvant to conventional antidiabetic therapies could be an effective approach to manage DN in humans. However, evidence is scarce to support whether resveratrol has beneficial effects in humans during DN. Therefore, clinical studies are warranted to elucidate resveratrol's role against DN.

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