Evaluation of the efficacy of chlorogenic acid in reducing small intestine injury, oxidative stress, and inflammation in chickens challenged with Clostridium perfringens type A

文献类型： 外文期刊

第一作者： Zhang, Xinheng

作者： Zhang, Xinheng;Zhao, Qiqi;Ci, Xiaotong;Chen, Sheng;Xie, Zi;Li, Hongxin;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Li, Hongxin;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Li, Hongxin;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Xie, Zi;Li, Hongxin;Chen, Feng;Xie, Qingmei;Zhang, Xinheng;Zhao, Qiqi;Ci, Xiaotong;Chen, Sheng;Xie, Zi;Li, Hongxin;Chen, Feng;Xie, Qingmei;Zhang, Huanmin

作者机构：

关键词： C. perfringens type A; chlorogenic acid; intestinal injury; oxidative stress; inflammation

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN：

年卷期： 2020 年 99 卷 12 期

页码：

收录情况： SCI

摘要： The goal of the study was testing the effects of chlorogenic acid (CA) supplementation on small intestine healthiness, growth performance, oxidative stress, inflammatory response, and blood biochemical indices in specific-pathogen-free (SPF) chickens after infection with Clostridium perfringens (CP) type A. In this study, 324 1-day-old male SPF chickens were randomly distributed into 6 groups: control group; CA group; CP infection group; CA + CP group; antibiotic group; antibiotic + CP group. All 1-day-old chickens were fed with CA or antibiotic in corresponding treatment group for 13 d. On the 14 d, the chickens in corresponding infection group were challenged with CP type A for 3 d. Samples in each group were collected when the chickens were 17 and 21 d old. This study proves for the first time that CA, a Chinese herbal medicine, can effectively improve growth performance, inhibit small intestine structural damage, improve antioxidant capacity, inhibit damage to ileal mucosal layer construction and tight junctions, inhibit inflammatory cytokines, and ameliorate blood biochemical indices. Therefore, this study provides data for CA being able to effectively alleviate small intestine damage caused by CP type A infection in chickens.

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