Characterization of integrons and antimicrobial resistance in Salmonella from broilers in Shandong, China

文献类型： 外文期刊

第一作者： Zhao, Xiaonan

作者： Zhao, Xiaonan;Hu, Ming;Zhang, Qing;Zhang, Yin;Li, Lulu;Qi, Jing;Luo, Yanbo;Liu, Yuqing;Zhao, Cui;Zhou, Dong

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关键词： Salmonella; broiler; antimicrobial susceptibility; class 1 integron; MLST

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

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年卷期： 2020 年 99 卷 12 期

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收录情况： SCI

摘要： Salmonella spp. are one of the most important foodborne bacterial pathogens in human beings and animals. This study aimed to analyze the prevalence and characterization of Salmonella from broilers in Shandong, China. A total of 67 Salmonella were recovered from 600 rectal swabs collected from 3 large-scale intensive broiler farms (67/600, 11.2%) between May and October 2018. Among Salmonella isolates, the most common serovars were S. enteritidis and S. typhimurium. The highest occurrence of resistance observed was for polymyxin (100%), followed by ampicillin (68.7%). The multidrug-resistant Salmonella isolation rate was observed to be 53.7%. Four beta-lactamase genes were detected among the isolates, and all the isolates carried bla(TEM) (67/67, 100%), followed by bla(OXA) (19/67, 28.4%), bla(CTX-M) (17/67, 25.4%), and bla(PSE) (7/67, 10.4%). Four plasmid-mediated quinolone resistance gene were detected among the isolates; the prevalent resistance genes was aac(60)-Ib-cr (18/67, 26.9%), followed by oqxB (9/67, 13.4%), qnrB (6/67, 9.0%), and qnrD (1/67, 1.5%). The prevalent rate of mcr-1 was 6.0% (4/67). Class 1 integrons were detected in 26.9% of these isolates and contained 7 groups of resistance gene cassettes. Multilocus sequence typing analysis revealed 7 sequence types, and ST11 was the most frequent sequence types. This study indicated that reduction of Salmonella and strict control on the use of antibiotics in more than 5,000 million broilers in Shandong are the vitally important measures to keep public health.

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