The Combination of CD8 alpha alpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gamma delta T Cells Response

文献类型： 外文期刊

第一作者： Liu, Yanjie

作者： Liu, Yanjie;Chen, Rong;Liang, Ruiying;Sun, Beibei;Wu, Yanan;Zhang, Lijie;Xia, Chun;Liu, Yanjie;Kaufman, Jim;Kaufman, Jim

作者机构：

关键词： chicken gamma delta T cells response; CD8/pMHC-I interaction; face-to-face mode; cCD8 alpha alpha/pBF2(star)1501; cCD8 alpha alpha/pBF2(star)0401

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）

ISSN： 1664-3224

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： The CD8 alpha alpha homodimer is crucial to both thymic T cell selection and the antigen recognition of cytotoxic T cells. The CD8-pMHC-I interaction can enhance CTL immunity via stabilizing the TCR-pMHC-I interaction and optimizing the cross-reactivity and Ag sensitivity of CD8(+) T cells at various stages of development. To date, only human and mouse CD8-pMHC-I complexes have been determined. Here, we resolved the pBF2(star)1501 complex and the cCD8 alpha alpha/pBF2(star)1501 and cCD8 alpha alpha/pBF2(star)0401 complexes in nonmammals for the first time. Remarkably, cCD8 alpha alpha/pBF2(star)1501 and the cCD8 alpha alpha/pBF2(star)0401 complex both exhibited two binding modes, including an "antibody-like" mode similar to that of the known mammal CD8/pMHC-I complexes and a "face-to-face" mode that has been observed only in chickens to date. Compared to the "antibody-like" mode, the "face-to-face" binding mode changes the binding orientation of the cCD8 alpha alpha homodimer to pMHC-I, which might facilitate abundant gamma delta T cells to bind diverse peptides presented by limited BF2 alleles in chicken. Moreover, the forces involving in the interaction of cCD8 alpha alpha/pBF2(star)1501 and the cCD8 alpha alpha/pBF2(star)0401 are different in this two binding model, which might change the strength of the CD8-pMHC-I interaction, amplifying T cell cross-reactivity in chickens. The coreceptor CD8 alpha alpha of TCR has evolved two peptide-MHC-I binding patterns in chickens, which might enhance the T cell response to major or emerging pathogens, including chicken-derived pathogens that are relevant to human health, such as high-pathogenicity influenza viruses.

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