Ameliorative effects of canolol against acrylamide toxicity in PC12 cells through modulating MAPKs pathway and autophagy
文献类型： 外文期刊
第一作者： Xia, Xiaoyang
作者： Xia, Xiaoyang;Zheng, Chang;Deng, Qianchun;Zheng, Mingming;Han, Ling;Xiang, Xia;Zhang, Zhen
作者机构：
关键词： Acrylamide; Toxicity; Canolol; MAPKs; Autophagy
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2020 年 75 卷
页码：
收录情况： SCI
摘要： Acrylamide (ACR), widely present in heat treatment of starchy foods, has attracted much attention in chronic neurotoxin. Canolol is a crucial phenolic compound and generated in rapeseed oil during microwave pressing. The present study aimed to reveal the ameliorative effects of canolol against ACR-induced toxicity in PC12 cells and the underlying mechanism. Cells pretreated with canolol inhibited ACR-exerted cytotoxicity and cell apoptosis. Canolol attenuated the increase of intracellular ROS and MDA level induced by ACR, and restored ACR-triggered depletion of glutathione content and mitochondrial membrane potential. Furthermore, canolol upregulated expressions of phosphorylated ERK1/2 protein, and downregulated phosphorylated p38 and JNK proteins after 24 h pretreatment in ACR-treated PC12 cells. Notably, ACR-stimulated autophagy activation was hindered by canolol in counteracting ACR-exerted LC-3 conversion and promoting the expression of p62 protein. Our study demonstrated that canolol prevented ACR damage involving MAPKs pathway and autophagy in PC12 cells, providing a potential application of canolol for ACR toxicity.
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