Three-component reactions of aromatic amines, 1,3-dicarbonyl compounds, and alpha-bromoacetaldehyde acetal to access N-(hetero)aryl-4,5-unsubstituted pyrroles
文献类型： 外文期刊
第一作者： Huang, Wenbo
作者： Huang, Wenbo;Wang, Kaimei;Ke, Shaoyong;Liu, Ping;Gu, Yanlong;Li, Minghao;Gu, Yanlong
作者机构：
关键词： acid catalyst; [1+2+2] annulation; KI; pyrazolo[3,4-b]pyridine; pyrroles
期刊名称：BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：2.883； 五年影响因子：2.785 ）
ISSN： 1860-5397
年卷期： 2020 年 16 卷
页码：
收录情况： SCI
摘要： N-(Hetero)aryl-4,5-unsubstituted pyrroles were synthesized from (hetero)arylamines, 1,3-dicarbonyl compounds, and alpha-bromoacetaldehyde acetal by using aluminum(III) chloride as a Lewis acid catalyst through [1 + 2 + 2] annulation. This new versatile methodology provides a wide scope for the synthesis of different functional N-(hetero)aryl-4,5-unsubstituted pyrrole scaffolds, which can be further derived to access multisubstituted pyrrole-3-carboxamides. In the presence of 1.2 equiv of KI, a polysubstituted pyrazolo[3,4-b]pyridine derivative was also successfully synthesized.
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