Four new sesquiterpene lactones from Atractylodes macrocephala and their CREB agonistic activities
文献类型： 外文期刊
第一作者： Wang, Pan
作者： Wang, Pan;Xie, Zhi-Shen;Song, Jun-Ying;Zeng, Hua-Hui;Xu, Jiang-Yan;Zhang, Zhen-Qiang;Wang, Pan;Ye, Zhi-Peng;Gao, Song;Dai, Li-Ping;E, Heng-Chao
作者机构：
关键词： Atractylodes macrocephala; Sesquiterpenoid lactone; Bisesquiterpenoid; Atractylenolide; CREB agonist
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2020 年 147 卷
页码：
收录情况： SCI
摘要： One new bisesquiterpenoid, biepiasreorlid II (1), three new sesquiterpene lactones 8 alpha-methoxy-epiasterolid (4), 3 beta-acetoxyl-8-epiasterolid (5), and 3 beta-acetoxyl-atractylenolide I (6), along with five known analogues (2-3 and 7-9), were obtained from rhizome of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by the analysis of single-crystal X-ray diffraction with Ga K alpha radiation, and 4-6 were elucidated by TDDFT-ECD calculations. The CREB agonistic activity was investigated in HEK293T cells using dual luciferase reporter assay. Compounds 1, 2, 5, and 7-9 exhibited strong to agonistic activities on CREB.
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