Novel Inactivated Subtype B Avian Metapneumovirus Vaccine Induced Humoral and Cellular Immune Responses

文献类型： 外文期刊

第一作者： Bao, Yuanling

作者： Bao, Yuanling;Yu, Mengmeng;Liu, Peng;Muhammad, Farooque;Wang, Zhihao;Li, Xinyi;Zhang, Zhuo;Wang, Suyan;Chen, Yuntong;Cui, Hongyu;Liu, Aijing;Qi, Xiaole;Pan, Qing;Zhang, Yanping;Gao, Li;Li, Kai;Liu, Changjun;He, Xijun;Wang, Xiaomei;Gao, Yulong;Hou, Fujun

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关键词： avian metapneumovirus; inactivated vaccine; adjuvant

期刊名称：VACCINES （ 影响因子：4.422； 五年影响因子：5.513 ）

ISSN：

年卷期： 2020 年 8 卷 4 期

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收录情况： SCI

摘要： Avian metapneumovirus (aMPV), a highly contagious agent, is widespread and causes acute upper respiratory tract disease in chickens and turkeys. However, currently, there is no vaccine licensed in China. Herein, we describe the development of an inactivated aMPV/B vaccine using the aMPV/B strain LN16. Combined with a novel adjuvant containing immune-stimulating complexes (ISCOMs), the novel vaccine could induce high virus-specific and VN antibodies. In addition, it activated B and T lymphocytes and promoted the expression of IL-4 and IFN-gamma. Importantly, boosting vaccination with the inactivated aMPV/B vaccine could provide 100% protection against aMPV/B infection with reduced virus shedding and turbinate inflammation. The protection efficacy could last for at least 6 months. This study yielded a novel inactivated aMPV/B vaccine that could serve as the first vaccine candidate in China, thus contributing to the control of aMPV/B and promoting the development of the poultry industry.

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