Ras/Raf/MEK/ERK pathway axis mediated neurotoxicity induced by high-risk pesticide residue-Avermectin

文献类型： 外文期刊

第一作者： Zhu, Ting

作者： Zhu, Ting;Xie, Han-Zhong;Xie, Han-Zhong;Wang, Sheng-Hui;Li, Qing-Rong;Zhang, Sai-Yang;Wang, Sheng-Hui;Zhang, Sai-Yang;Zhu, Ting;Liu, Xu;Song, Jian;Li, Dong;Pang, Xiao-Jing;Fu, Dong-Jun;Zhang, Sai-Yang;Zhu, Ting;Zhang, Sai-Yang

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关键词： Avermectin; chronic toxicology; ERK pathway; high risk; neurotoxicity

期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）

ISSN： 1520-4081

年卷期： 2021 年 36 卷 5 期

页码：

收录情况： SCI

摘要： Pesticide residues have become a healthy threaten of human beings. Among the pesticides, many of them have neurotoxicity. Extracellular Regulated Protein Kinases (ERK) pathway is an important signaling pathway that regulates a variety of downstream progress. In this work, peach (PRUNUS persica) and cherry (PRUNUS cerasus) were sampled from over 300 plantations in China and assessed for the residue risk. In mechanism studies, high-risk pesticide Avermectin showed a high activity inhibiting three neurotoxicity models, SH-SY5Y, PC-12 and SK-N-SH cells. At protein levels, ERK pathway proteins and their downstream proteins were obviously down-regulated. Moreover, the effects of low-dose Avermectin can be accumulated at protein levels in the low-dose long-term chronic toxicology detection.

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