A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring

文献类型： 外文期刊

第一作者： Hu, Chengjun

作者： Hu, Chengjun;Yang, Yunyu;Chen, Minxia;Hao, Xiangyu;Wang, Shuqi;Yin, Yulong;Tan, Chengquan;Hu, Chengjun;Yin, Yulong;Yang, Linfang

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关键词： High fat; low fiber diet; Glucose tolerance; Mitochondrial function; Muscle fiber; Pregnancy

期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：5.614； 五年影响因子：5.286 ）

ISSN： 1436-6207

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收录情况： SCI

摘要： Purpose In our previous study, the maternal high-fat/low-fiber (HF-LF) diet was suggested to induce metabolic disorders and placental dysfunction of the dam, but the effects of this diet on glucose metabolism of neonatal offspring remain largely unknown. Here, a neonatal pig model was used to evaluate the effects of maternal HF-LF diet during pregnancy on glucose tolerance, transition of skeletal muscle fiber types, and mitochondrial function in offspring. Methods A total of 66 pregnant gilts (Guangdong Small-ear Spotted pig) at day 60 of gestation were randomly divided into two groups: control group (CON group; 2.86% crude fat, 9.37% crude fiber), and high-fat/low-fiber diet group (HF-LF group; 5.99% crude fat, 4.13% crude fiber). Results The maternal HF-LF diet was shown to impair the glucose tolerance of neonatal offspring, downregulate the protein level of slow-twitch fiber myosin heavy chain I (MyHC I), and upregulate the protein levels of fast-twitch fiber myosin heavy chain IIb (MyHC IIb) and IIx (MyHC IIx) in soleus muscle. Additionally, compared with the CON group, the HF-LF offspring showed inhibition of insulin signaling pathway and decrease in mitochondrial function in liver and soleus muscle. Conclusion Maternal HF-LF diet during pregnancy impairs glucose tolerance, induces the formation of glycolytic muscle fibers, and decreases the hepatic and muscular mitochondrial function in neonatal piglets.

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