Improved Therapeutic Efficacy of Topotecan against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

文献类型： 外文期刊

第一作者： Zhang, Jingxin

作者： Zhang, Jingxin;Ma, Qiang;Cui, Haixin;Zhang, Liang;Shi, Weiyue;Xue, Gangqiang

作者机构：

关键词： Lung cancer; folate-targeted topotecan liposomes; sustained drug release; pharmacokinetics; antitumor efficiency; folate-specific targeting

期刊名称：CURRENT DRUG METABOLISM （ 影响因子：3.731； 五年影响因子：3.601 ）

ISSN： 1389-2002

年卷期： 2020 年 21 卷 11 期

页码：

收录情况： SCI

摘要： Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan tiposomes with folate, and the tiposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan Liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan Liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

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