Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities
文献类型： 外文期刊
第一作者： Geng, Hui-Chun
作者： Geng, Hui-Chun;Zhu, Hong-Tao;Wang, Dong;Yang, Chong-Ren;Zhang, Ying-Jun;Geng, Hui-Chun;Geng, Hui-Chun;Yang, Wei-Nong
作者机构：
关键词： Phyllanthus acidus; Cleistanthane diterpenoids; Cytotoxicity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2021 年 148 卷
页码：
收录情况： SCI
摘要： Phytochemical investigation on the nonpolar extracts of P. acidus leaves afforded three new cleistanthane diterpenoids, named phyllanacidins A-C (1-3) 5 in addition to three known ones (4-6). Among them, compounds 2 and 3 represent the first examples of 17-nor cleistanthane diterpenoids. Their structures including absolute configurations were elucidated on the basis of extensive spectroscopic data and single crystal X-ray diffraction analysis. All the isolated cleistanthane diterpenoids were evaluated for their cytotoxic activities against five human cancer cell lines. Compounds 4-6 exhibited moderate cytotoxicity with IC50 values ranging from 16.11 to 30.82 mu M.
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