Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells

文献类型： 外文期刊

第一作者： Wang, Qi

作者： Wang, Qi;Guan, Xuefang;Lai, Chengchun;Gao, Huiying;Huang, Juqing;Lin, Bin;Wang, Qi;Guan, Xuefang;Lai, Chengchun;Gao, Huiying;Huang, Juqing;Lin, Bin;Zheng, Yafeng

作者机构：

关键词： Oolong tea; Selenium; Human hepatoma cell; Anti-proliferative effect; Apoptosis

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2021 年 147 卷

页码：

收录情况： SCI

摘要： Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 mu g selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 mu g selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 mu g/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that SeTE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序