Foot-and-Mouth Disease Virus Inhibits RIP2 Protein Expression to Promote Viral Replication

文献类型： 外文期刊

第一作者： Liu, Huisheng

作者： Liu, Huisheng;Xue, Qiao;Zhu, Zixiang;Yang, Fan;Cao, Weijun;Liu, Xiangtao;Zheng, Haixue

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关键词： Foot-and-mouth disease virus (FMDV); Receptors interaction protein 2 (RIP2); PABPC1; 2C; Immune evasion

期刊名称：VIROLOGICA SINICA （ 影响因子：4.327； 五年影响因子：4.08 ）

ISSN： 1674-0769

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收录情况： SCI

摘要： Receptors interaction protein 2 (RIP2) is a specific adaptor molecule in the downstream of NOD2. The role of RIP2 during foot-and-mouth disease virus (FMDV) infection remains unknown. Here, our results showed that RIP2 inhibited FMDV replication and played an important role in the activation of IFN-beta and NF-B signal pathways during FMDV infection. FMDV infection triggered RIP2 transcription, while it reduced the expression of RIP2 protein. Detailed analysis showed that FMDV 2B, 2C, 3C(pro), and L-pro proteins were responsible for inducing the reduction of RIP2 protein. 3C(pro) and L-pro are viral proteinases that can induce the cleavage or reduction of many host proteins and block host protein synthesis. The carboxyl terminal 105-114 and 135-144 regions of 2B were essential for reduction of RIP2. Our results also showed that the N terminal 1-61 region of 2C were essential for the reduction of RIP2. The 2C-induced reduction of RIP2 was dependent on inducing the reduction of poly(A)-binding protein 1 (PABPC1). The interaction between RIP2 and 2C was observed in the context of viral infection, and the residues 1-61 were required for the interaction. These data clarify novel mechanisms of reduction of RIP2 mediated by FMDV.

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