Unravelling bioaccumulation, depletion and metabolism of organophosphate triesters in laying hens: Insight of in vivo biotransformation assisted by diester metabolites

文献类型： 外文期刊

第一作者： Yin, Yuhan

作者： Yin, Yuhan;Zhao, Nannan;Xiao, Zhiming;Wang, Ruiguo;Wang, Peilong;Li, Xiaomin;Pan, Wenxiao;Xue, Qiao;Fu, Jie

作者机构：

关键词： Organophosphate triesters; Diester metabolites; In vivo behavior; Laying hens ' tissues; Accumulation/depletion kinetics; In silico modeling

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）

ISSN： 0304-3894

年卷期： 2024 年 466 卷

页码：

收录情况： SCI

摘要： Organophosphate triesters (tri-OPEs) threaten human health through dietary exposure, but little is known about their feed-to-food transfer and in vivo behavior in farm animals. Herein 135 laying hens were fed with contaminated feed (control group, low-level group and high-level group) to elucidate the bioaccumulation, distribution, and metabolism of the six most commonly reported tri-OPEs. The storage (breast muscle), metabolism and mobilization (liver and blood) and non-invasive (feather) tissues were collected. The exposureincrease (D1-14) and depuration-decrease (D15-42) trends indicated that feed exposure caused tri-OPE accumulation in animal tissues. Tissue-specific and moiety-specific behavior was observed for tri-OPEs. The highest transfer factor (TF) and transfer rate (TR) were observed in liver (TF: 14.8%-82.3%; TR: 4.40%-24.5%), followed by feather, breast muscle, and blood. Tris(2-chloroisopropyl) phosphate (TCIPP) had the longest halflife in feather (72.2 days), while triphenyl phosphate (TPhP) showed the shortest half-life in liver (0.41 days). Tri-OPEs' major metabolites (organophosphate diesters, di-OPEs) were simultaneously studied, which exhibited dose -dependent and time -dependent variations following administration. In breast muscle, the inclusion of di- OPEs resulted in TF increases of 735%, 1108%, 798%, and 286% than considering TCIPP, tributyl phosphate, tris(2-butoxyethyl) phosphate and tris(2-ethylhexyl) phosphate alone. Feather was more of a proxy of birds' long-term exposure to tri-OPEs, while short-term exposure was better reflected by di-OPEs. Both experimental and in silico modeling methods validated aryl -functional group facilitated the initial accumulation and meta- bolism of TPhP in the avian liver compared to other moiety -substituted tri-OPEs.

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