Anti-Inflammatory and Photoaging-Protective Effects of Olea europaea through Inhibition of AP-1 and NF-kappa B Pathways

文献类型： 外文期刊

第一作者： Song, Chaoran

作者： Song, Chaoran;Jeong, Deok;Hong, Yo Han;Kim, Ji Hye;Cho, Jae Youl;Song, Chaoran;Jeong, Deok;Hong, Yo Han;Kim, Ji Hye;Cho, Jae Youl;Li, Wan Yi;Lee, Sang Woo;Hossain, Mohammad Amjad;Kim, Jong-Hoon;Taamalli, Amani;Taamalli, Amani

作者机构：

关键词： Olea europaea; Antiphotoaging Effect; Anti-Inflammatory Effect; AP-1; NF-kappa B

期刊名称：AMERICAN JOURNAL OF CHINESE MEDICINE （ 影响因子：4.667； 五年影响因子：4.135 ）

ISSN： 0192-415X

年卷期： 2020 年 48 卷 8 期

页码：

收录情况： SCI

摘要： Olea europaea is a beneficial edible plant with a number of biological activities like anti-inflammatory, anti-oxidant, antithrombic, antihyperglycemic, and anti-ischemic activities. The mechanisms behind the antiphotoaging and anti-inflammatory effects of Olea europaea are not fully understood. To investigate how an ethanol extract of Olea europaea (Oe-EE) exerts these effects, we explored its activities in human keratinocytes and dermal fibroblasts. We assessed the anti-oxidant effects of Oe-EE via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays and measured the expression levels of matrix metalloproteinases (MMPs), cyclooxygenase-2, interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and moisturizing factors. Antiphotoaging and anti-inflammatory mechanisms of Oe-EE were explored by assessing signaling molecule activation via immunoblotting. Oe-EE treatment decreased the mRNA expression level of MMPs, cyclooxygenase-2, IL-6, and TNF-alpha and restored type I collagen, filaggrin, and sirtuin 1 expression in UVB-irradiated cells. Furthermore, Oe-EE inhibited the activities of several activator protein 1 regulatory enzymes, including extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), and inhibited nuclear factor (NF)-kappa B pathway signaling proteins. Therefore, our results indicate that Oe-EE has photoaging-protective and anti-inflammatory effects.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序