Anti-Inflammatory Dimeric and Trimeric Flavonoids from the Roots ofPistacia weinmannifolia

文献类型： 外文期刊

第一作者： Lee, Seong Mi

作者： Lee, Seong Mi;Ryu, Hyung Won;Kim, Hyoung-Geun;Jo, Yang Hee;Lee, Su Ui;Oh, Eun Sol;Oh, Sei-Ryang;Lee, Seong Mi;Ryu, Hyung Won;Kim, Hyoung-Geun;Jo, Yang Hee;Lee, Su Ui;Oh, Eun Sol;Oh, Sei-Ryang;Lee, Seong Mi;Hwang, Bang Yeon;Lee, Seong Mi;Park, Kyoung Jin;Lee, Sang Woo;Choi, Sangho;Li, Wan-Yi

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）

ISSN： 0163-3864

年卷期： 2025 年 88 卷 2 期

页码：

收录情况： SCI

摘要： As part of an ongoing search for new anti-inflammatory agents from medicinal plants, five new dimeric and trimeric flavonoids (1-5) were isolated from the roots of Pistacia weinmannifolia. The structures of pistachalcone A (1), pistachalcone B (2), pistaflavanone A (3), pistachalcone C (4), and pistachalcone D (5) were elucidated by the analysis of spectroscopic data. The known compounds rhuschalcone II (6), rhuschalcone VI (7), and pauferrol B (8) were also isolated and identified. Our in vitro analysis found that compounds isolated from P. weinmannifolia root extract exert anti-inflammatory effects in phorbol myristate acetate (PMA)-induced NCI-H292 airway epithelial cells by the suppression of expression levels such as interleukin-8 (IL-8) and mucin 5AC (MUC5AC), which are closely related to the pulmonary inflammatory response in the pathogenesis of COPD. Therefore, these dihydrochalcone derivatives may have value as new starting materials for the development of drug candidates against COPD.

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