The biological characteristics of the canine adenovirus type 1 from fox and the transcriptome analysis of the infected MDCK cell

文献类型： 外文期刊

第一作者： Zhu, Yanzhu

作者： Zhu, Yanzhu;Lian, Shizhen;Hu, Bo;Lv, Shuang;Li, Yali;Yan, Xijun;Sun, Jie;Yan, Minghao;Zhang, Yufei;Yan, Xijun

作者机构：

关键词： biological characterization; canine adenovirus 1; MDCK cell; transcriptome analysis

期刊名称：CELL BIOLOGY INTERNATIONAL （ 影响因子：3.612； 五年影响因子：3.055 ）

ISSN： 1065-6995

年卷期： 2021 年 45 卷 5 期

页码：

收录情况： SCI

摘要： Canine adenovirus type 1 (CAdV-1) is the etiologic agent of fox encephalitis, and a virus strain from fox encephalitis is isolated and related research are conducted. In this experiment, the results showed that the F1301 strain was confirmed to be the CAdV-1. The whole genome of the CAdV-1 F1301 strain isolated from fox was 30,535 bp and had higher homology to the other reported CAdV-1 strains. After 0, 12, and 36 h of CAdV-1 infection, the difference gene of the 592 long noncoding RNA and 11,215 microRNA were involved in cell responses to CAdV-1 infection through the PI3K-AKT, Wnt, Herpes simplex, hepatitis C, and Epstein-Barr virus infection pathway in Madin-Darby canine kidney cell line (MDCK). The results indicate that the biological characterization of the CAdV-1 and the MDCK cell-CAdV-1 interaction are clarified.

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