Novel Macrolactams from a Deep-Sea-Derived Streptomyces Species

文献类型： 外文期刊

第一作者： Wang, Pei

作者： Wang, Pei;Wang, Dongyang;Zhang, Rongxin;Wang, Yi;Kong, Fandong;Fu, Peng;Zhu, Weiming;Wang, Pei;Kong, Fandong;Fu, Peng;Zhu, Weiming

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关键词： macrolactam; Deep-Sea-Derived Streptomyces; abiotic formation; natural product; antifungal activity

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

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年卷期： 2021 年 19 卷 1 期

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收录情况： SCI

摘要： Four polyene macrolactams including the previously reported niizalactam C (4), and three new ones, streptolactams A-C (1-3) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived Streptomyces sp. OUCMDZ-3159. Their structures were determined based on spectroscopic analysis, X-ray diffraction analysis, and chemical methods. The abiotic formation of compounds 2 and 4 from compound 1 were confirmed by a series of chemical reactions under heat and light conditions. Compounds 1 and 3 showed a selective antifungal activity against Candida albicans ATCC 10231.

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