Effects of exopolysaccharide from Lactobacillus rhamnosus on human gut microbiota in in vitro fermentation model

文献类型： 外文期刊

第一作者： Zhu, Yuzhu

作者： Zhu, Yuzhu;Zhou, Jia-Min;Zhou, Qingqing;Li, Ping;Zhou, Tao;Gu, Qing;Liu, Wei;Pi, Xionge

作者机构：

关键词： Lactobacillus rhamnosus; Exopolysaccharide; In vitro fermentation; Gut microbiota

期刊名称：LWT-FOOD SCIENCE AND TECHNOLOGY （ 影响因子：4.952； 五年影响因子：5.383 ）

ISSN： 0023-6438

年卷期： 2021 年 139 卷

页码：

收录情况： SCI

摘要： Exopolysaccharides (EPS) produced by some bacteria have prebiotic potential and contribute to the regulation of the gut microbiota. Four types of EPS with different molecular composition from Lactobacillus rhamnosus ZFM231 were identified. In this work, we evaluated the potential of EPS on human gut microbiota by in vitro fermentation model. It was found that purified EPS fractions were degraded effectively by human gut microbiota. Gas chromatography (GC) assay revealed that EPS could be fermented to produce short chain fatty acids (SCFAs) by gut microbiota in human fecal samples from twelve healthy volunteers. 16S rDNA sequencing showed that EPS mainly increased the abundance of Ruminococcus, Dorea, Butyricicoccus, Blautia and others. The current research provides valuable new information on the mechanisms of absorption, utilization and functional activity of Lactobacillus rhamnosus EPS in the gastrointestinal tract of the human body.

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