Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp.
文献类型： 外文期刊
第一作者： Li, Kun-Long
作者： Li, Kun-Long;Dai, Yu;She, Jiang-Lian;Zhou, Xue-Feng;Liu, Yong-Hong;Li, Kun-Long;Dai, Yu;She, Jiang-Lian;Liu, Yong-Hong;Li, Kun-Long;Zhou, Xue-Feng;Liu, Yong-Hong;Zeng, Yan-Bo;Dai, Hao-Fu;Ou, Shun-Ling;Liu, Yong-Hong
作者机构：
关键词： Bisabolanoic acid A; mangrove-derived fungus; AChE inhibitory; absolute configuration
期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）
ISSN： 1028-6020
年卷期：
页码：
收录情况： SCI
摘要： A new polychiral bisabolane sesquiterpene, bisabolanoic acid A (1), was isolated from the mangrove-derived fungus Colletotrichum sp. SCSIO KcB3-2. Its planar structure was identified on the basis of spectroscopic data analysis (HRESIMS, 1D, and 2D NMR), and the absolute configurations of three chiral carbons were determined by experimental and calculated electronic circular dichroism (ECD) and optical rotatory dispersion (ORD), together with Mo-2(OAc)(4)-induced ECD methods. Bisabolanoic acid A (1) showed moderate inhibitory activity against acetylcholinesterase (AChE) with IC50 value of 2.2 mu M, and the in silico molecular docking was also performed.
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