Three new dimeric 2-(2-phenethyl)chromones from the agarwood of Aquilaria malaccensis

文献类型： 外文期刊

第一作者： Yan, Xian-Yun

作者： Yan, Xian-Yun;Liang, Lin-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu

作者机构：

关键词： Agarwood; Aquilaria malaccensis; 2-(2-phenethyl)chromone dimers; Anti-inflammatory activity

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.4； 五年影响因子：1.5 ）

ISSN： 1874-3900

年卷期： 2025 年 66 卷

页码：

收录情况： SCI

摘要： Three unreported 2-(2-phenethyl)chromone dimers, malaccenones A-C (1-3), were isolated and identified from the agarwood Aquilaria malaccensis. These compounds were purified by various column chromatographic techniques, and their structures were elucidated based on the analysis of UV, HRESIMS, 1D and 2D NMR, and ECD spectroscopic data, as well as comparison with literature data. Compounds 1-3 were evaluated for their inhibition effects on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells. All of these compounds exhibited anti-inflammatory activity with IC50 values ranging from 21.79 +/- 1.05-31.44 +/- 1.65 mu M.

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