High-throughput method based on a novel thin-film microextraction coating for determining macrolides and lincosamides in honey

文献类型： 外文期刊

第一作者： Zhang, Xiaoming

作者： Zhang, Xiaoming;Wang, Jianmei;Zhao, Huiyu;Ji, Xiaofeng;Xu, Yan;Li, Rui;Zhang, Hu;Yang, Hua;Qian, Mingrong;Zhang, Xiaoming;Li, Zuguang;Xu, Yan;Wu, Huizhen

作者机构：

关键词： Thin-film microextraction; ZIF-8@GO; Honey; Macrolides; Lincosamides

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2021 年 346 卷

页码：

收录情况： SCI

摘要： A high-throughput method using a new ZIF-8@GO thin-film microextraction coating was established for determining macrolides and lincosamides in honey. The coating preparation parameters (ZIF-8@GO synthesis conditions, coating material proportions, dipping time) and analysis parameters (sample diluent solvent, adsorption and desorption conditions using the ZIF-8@GO coating) were optimized. The optimized parameters were: diluent solvent sodium carbonate/sodium bicarbonate buffer solution (pH 9), adsorption time 45 min, desorption time 5 min, desorption solvent 45:40:15 v/v/v methanol/acetonitrile/water. The extracted targets were determined by ultra-high performance liquid chromatography tandem mass spectrometry. The recoveries of 10 analytes were 67.5-107.2% and the detection and quantification limits were 0.1-0.4 and 0.4-1.4 mu g/kg, respectively. The method could analyze 96 samples per run. The minimal manual time and effort is required since the bulk of the sample processing is fully automated. It was a useful and efficient method for monitoring drug residues and was successfully used to analyze real samples.

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