Acetate stimulates lipogenesis via AMPK alpha signaling in rabbit adipose-derived stem cells

文献类型： 外文期刊

第一作者： Liu, Lei

作者： Liu, Lei;Fu, Chunyan;Li, Fuchang;Liu, Yongxu;Fu, Chunyan

作者机构：

关键词： Acetate; Rabbit adipose-derived stem cells; Signaling pathways; Lipometabolism

期刊名称：GENERAL AND COMPARATIVE ENDOCRINOLOGY （ 影响因子：2.822； 五年影响因子：2.772 ）

ISSN： 0016-6480

年卷期： 2021 年 303 卷

页码：

收录情况： SCI

摘要： Acetate plays an important role in host lipid metabolism. However, the regulatory network underlying acetate-regulated lipometabolism remains unclear. The aim of this study was to determine whether any cross talk occurs among adenosine 5'-monophosphate-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPKs) and acetate in regulating lipid metabolism. The compound C (an AMPK inhibitor), and SB203580 (a p38 MAPK inhibitor) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively. It indicated that acetate (6 mM) for 6 h increased the lipid deposition in rabbit ADSCs. Besides, acetate treatment (6 mM) increased significantly phosphorylated protein level of AMPK alpha and p38 MAPK, but not altered significantly the phosphorylated protein level of extracellular signaling-regulated kinase (ERK) and c-Jun aminoterminal kinase (JNK). The blocking of AMPK alpha signaling attenuated acetate-induced lipid accumulation, but not that of p38 MAPK signaling. In conclusion, our findings suggest that AMPK alpha signaling pathway is associated with acetate-induced lipogenesis.

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