beta-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability

文献类型： 外文期刊

第一作者： Ma, Dongxue

作者： Ma, Dongxue;Min, Lingjiang;Han, Pengfei;Song, Mingji;Shen, Wei;Huang, Guian;Zhao, Minghui;Sun, Qingyuan;Zhao, Yong;Zhang, Hongfu;Zhao, Yong

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关键词： β -carotene; spermatogenesis; antioxidant; improvement; reactive oxygen species

期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：5.81； 五年影响因子：6.005 ）

ISSN： 1663-9812

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： beta-carotene, precursor of vitamin A, is an excellent antioxidant with many beneficial properties. It is a lipid-soluble antioxidant and a very effective quencher of reactive oxygen species (ROS) to reduce the oxidative stress. In contrast to vitamin A, beta-carotene is not toxic even consumed in higher amount when it is delivered from natural plant products. Recently, we found that beta-carotene acts as a potential antioxidant in the oocyte to improve its quality. Even though many studies have been reported that beta-carotene has the beneficial contribution to the ovarian development and steroidogenesis, it is unknown the effects of beta-carotene on the spermatogenesis. This investigation aimed to explore the hypothesis that beta-carotene could improve spermatogenesis and the underlying mechanism. And we found that beta-carotene rescued busulfan disrupted spermatogenesis in mouse with the increase in the sperm concentration and motility. beta-carotene improved the expression of genes/proteins important for spermatogenesis, such as VASA, DAZL, SYCP3, PGK2. Moreover, beta-carotene elevated the testicular antioxidant capability by the elevation of the antioxidant glutathione and antioxidant enzymes SOD, GPX1, catalase levels. In conclusion, beta-carotene may be applied for the infertile couples by the improvement of spermatogenesis, since, worldly many couples are infertile due to the idiopathic failed gametogenesis (spermatogenesis).

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