Iodine-catalyzed sulfuration of isoquinolin-1(2H)-ones applying ethyl sulfinates

文献类型： 外文期刊

第一作者： Mu, Yangxiu

作者： Mu, Yangxiu;Li, Fengxia;Iqbal, Zafar;Jiang, Rui;Hou, Jing;Tang, Dong;Yang, Minghua;Yang, Zhixiang;Tang, Dong;Guo, Xin

作者机构：

期刊名称：NEW JOURNAL OF CHEMISTRY （ 影响因子：3.288； 五年影响因子：3.153 ）

ISSN： 1144-0546

年卷期： 2021 年 45 卷 11 期

页码：

收录情况： SCI

摘要： An efficient sulfuration of isoquinolin-1(2H)-ones at the C-4 position is reported by employing ethyl sulfinates, and the corresponding products are obtained in moderate to excellent yields in the presence of iodine. This synthetic strategy provides a range of thioether-isoquinolin-1(2H)-ones while tolerating a number of functional groups on the isoquinoline nitrogen atom and benzene ring. In addition, pyridin-2(1H)-one is also reacted smoothly and afforded the corresponding thioether product in moderate yield. A plausible mechanism is suggested based on the preliminary mechanistic studies.

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