文献类型： 外文期刊
第一作者： Feng, Y.
作者： Feng, Y.;Liu, Y.;Gao, F.;Feng, Y.;Deng, Y.;Cirera, S.;Tasoz, E.;Olsen, L. H.;Pedersen, H. D.;Schumacher-Petersen, C.;Fredholm, M.;Gao, F.;Christoffersen, B. O.;Pedersen, H. D.;Ludvigsen, T. P.;Kirk, R. K.;Schumacher-Petersen, C.;Pedersen, H. D.
作者机构：
关键词： epigenetics; promoter DNA methylation; diet intervention; obesity; metabolism
期刊名称：FRONTIERS IN GENETICS （ 影响因子：3.258； 五年影响因子：4.005 ）
ISSN：
年卷期： 2021 年 12 卷
页码：
收录情况： SCI
摘要： Objective: Environmental factors can influence obesity by epigenetic mechanisms. The aim of this study was to investigate obesity-related epigenetic changes and the potential for reversal of these changes in the liver of Gottingen minipigs subjected to diet interventions. Methods: High-throughput liquid hybridization capture-based bisulfite sequencing (LHC-BS) was used to quantify the methylation status of gene promotor regions in liver tissue in three groups of male castrated Gottingen minipigs: a standard chow group (SD, N = 7); a group fed high fat/fructose/cholesterol diet (FFC, N = 10) and a group fed high fat/fructose/cholesterol diet during 7 months and reversed to standard diet for 6 months (FFC/SD, N = 12). Expression profiling by qPCR of selected metabolically relevant genes was performed in liver tissue from all pigs. Results: The pigs in the FFC diet group became morbidly obese. The FFC/SD diet did not result in a complete reversal of the body weight to the same weight as in the SD group, but it resulted in reversal of all lipid related metabolic parameters. Here we identified widespread differences in the patterning of cytosine methylation of promoters between the different feeding groups. By combining detection of differentially methylated genes with a rank-based hypergeometric overlap algorithm, we identified 160 genes showing differential methylation in corresponding promoter regions in the FFC diet group when comparing with both the SD and FFC/SD groups. As expected, this differential methylation under FFC diet intervention induced de-regulation of several metabolically-related genes involved in lipid/cholesterol metabolism, inflammatory response and fibrosis generation. Moreover, five genes, of which one is a fibrosis-related gene (MMP9), were still perturbed after diet reversion. Conclusion: Our findings highlight the potential of exploring diet-epigenome interactions for treatment of obesity.
分类号：
- 相关文献
作者其他论文 更多>>
-
Comparative transcriptomic analyses reveal key genes underlying melanin distribution during embryonic development in geese (Anser anser)
作者：Yang, Y.;Wang, C.;Liu, Y.;Li, G.;Wang, X.;Wang, H.;He, D.
关键词：Graylag geese; melanin; genetics; dorsal skin; distal feet
-
Organic selenium supplementation increases serum selenium levels in healthy Xinjiang brown cattle fed selenised yeast
作者：Li, Z.;Tang, J.;Li, J.;Ling, D.;He, X.;Tang, Y.;Yi, P.;Yang, Y.;Li, Z.;Li, J.;He, X.;Tang, Y.;Yi, P.;Tang, J.;Khoo, H. E.;Liu, Y.
关键词：blood metabolites; Bos taurus; enzyme activity; red dates; slaughter performance
-
Quercetin ameliorates lipid deposition in primary hepatocytes of the chicken embryo
作者：Feng, Y.;Zhao, C.;Li, T.;Wang, M.;Zhao, W.;Shen, M.;Serrano, B. R.;Barcenas, A. R.;Zhao, W.;Qu, L.;Shen, M.
关键词：Quercetin; chicken; fatty liver; SREBP-1; AKT; ERK
-
Effect of lipids on the stability of natural rubber latex and tensile properties of its films (vol 20, pg 213, 2017)
作者：Liu, H.;Wang, Q.;Li, J.;Liu, Y.;He, D.;Yu, H.;Gao, X.;Li, J.;Liu, Y.;He, D.
关键词：
-
Optimizing the Ultrasound-Assisted Extraction of Total Cardiac Glycosides from the Milk of Calotropis Gigantea with Response Surface Methodology
作者：Gao, Z. Y.;Gong, R.;Zha, F.;Gong, R.;Gao, F.
关键词：ultrasound-assisted extraction; cardiac glycoside; Calotropis gigantea; response surface method; Box-Behnken design
-
Low-depth Raw Reads of Nanopore Sequencing Enables Rapid and Accurate Bacterial Identification
作者：Gao, W.;Hong, W.;Wu, Y.;Liu, Y.;Fan, X.;Wang, H.;Wang, M.;Yang, B.;Wang, T.;Li, H.;Liu, S.;Li, J.
关键词：assembly; reads; Nanopore sequencing; Illumina sequencing; bacterial identification
-
First Report of Pectobacterium versatile Causing Diseases on Potato in Xinjiang Uygur Autonomous Region and Heilongjiang Province, China
作者：Handique, U.;Wu, Y. J.;Duan, J.;Lv, J.;Zhang, R. F.;Wu, J.;Liu, Y.
关键词：aerial stem rot; blackleg; China; Pectobacterium versatile; potato
