Development and validation of a multi-residue analytical method for veterinarian and human pharmaceuticals in livestock urine and blood using UHPLC-QTOF

文献类型： 外文期刊

第一作者： Wang, Xue

作者： Wang, Xue;Wang, Ke-wen;Xu, Zhen-zhen;Yang, Shu-ming;Zhao, Yan;Wang, Ke-wen

作者机构：

关键词： Drug residues; Livestock blood; Livestock urine; UHPLC-QTOF

期刊名称：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES （ 影响因子：3.004； 五年影响因子：2.841 ）

ISSN： 1570-0232

年卷期： 2021 年 1167 卷

页码：

收录情况： SCI

摘要： The aim of this work is to contribute to the assessment of multi-residue analysis of veterinarian and human pharmaceuticals using UHPLC-QTOF in livestock urine and blood (cattle, chicken, sheep and pig). Firstly, an in-house database including compound name, monoisotopic mass, chemical formula, retention time, chemical structure, and three CID MS-MS spectra of the 234 selected drugs were built for qualitative detection. Secondly, the method validation result showed that all the 234 drugs exhibited good linearity with determination co-efficients (R-2) higher than 0.999. Then, the distribution of the drugs recoveries, intra-day RSD and inter-day RSD results for all seven matrices were tested. Finally, after a carefully cross check, 150 veterinarian and human pharmaceuticals could meet the methodological requirements (recovery, 50-120%; intra-day RSD <= 15%, inter-day RSD <= 20%) in all seven matrices. Our results suggested that although the main applications of UHPLC-QTOF are directed towards detection and identification of the compounds, this method should be also applied for quantitative purposes.

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