文献类型： 外文期刊
第一作者： Zhang, Zhaobo
作者： Zhang, Zhaobo;Wang, Guoshuai;Feng, Siyu;Han, Kexin;Han, Limei;Zhang, Sishi;Han, Liping
作者机构：
关键词： Non-coding RNA; microRNA; Long non-coding RNA; Tumorigenesis; Chicken
期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：1.892； 五年影响因子：1.816 ）
ISSN： 0034-5288
年卷期： 2021 年 135 卷
页码：
收录情况： SCI
摘要： Marek?s disease virus (MDV), the causative agent of Marek?s disease (MD), results in highly infectious phymatosis, lymphatic tissue hyperplasia, and neoplasia. MD is associated with high morbidity and mortality rate. Noncoding RNAs (ncRNAs) entails long non-coding RNA (lncRNA) and microRNA (miRNA). Numerous studies have reported that specific miRNAs and lncRNAs participate in multiple cellular processes, such as proliferation, migration, and tumor cell invasion. Specialized miRNAs and lncRNAs militate a similar role in MD tumor oncogenesis. Despite its growing popularity, only a few reviews are available on ncRNA in MDV tumor oncogenes. Herein, we summarized the role of the miRNAs and lncRNAs in MD tumorigenesis. Altogether, we brought forth the research issues, such as MD prevention, screening, regulatory network formation, novel miRNAs, and lncRNAs analysis in MD that needs to be explored further. This review provides a theoretical platform for the further analysis of miRNAs and lncRNAs functions and the prevention and control of MD and malignancies in domestic animals.
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