文献类型： 外文期刊
第一作者： Xiong, Mingfu
作者： Xiong, Mingfu;Zhang, Yongsheng;Xiong, Mingfu;Yao, Yilong;Chen, Yun;Wang, Shilong;Zhang, Zhaobo;Fan, Danyang;He, Xia;Yao, Yilong;Li, Jiaying
作者机构：
关键词： Skeletal muscle; LLPS; Development; Diseases
期刊名称：DEVELOPMENTAL BIOLOGY （ 影响因子：2.1； 五年影响因子：2.5 ）
ISSN： 0012-1606
年卷期： 2025 年 527 卷
页码：
收录情况： SCI
摘要： Liquid-liquid phase separation (LLPS) is a crucial biophysical process that enables dynamic compartmentalization within cells, gaining prominence in recent research on cellular organization. However, its implications for skeletal muscle-a vital tissue for movement and metabolic regulation-remain largely uncharted. This review highlights recent insights into LLPS's roles in other tissues while examining its potential functions in skeletal muscle development, regeneration, and disease. By synthesizing existing knowledge, we propose that exploring LLPS in skeletal muscle could uncover fundamental aspects of muscle physiology and offer innovative therapeutic avenues for muscle-related disorders. A deeper grasp of LLPS may thus transform our understanding and treatment of skeletal muscle pathologies.
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