Low METTL3 level in midgut of the Bombyx mori inhibit the proliferation of nucleopolyhedrovirus

文献类型： 外文期刊

第一作者： Xue, Peng

作者： Xue, Peng;Jiang, Tao;Zhu, Juan;Wang, Meixian;Zhao, Qiaoling;Huang, Jinshan;Tang, Shunming;Shen, Xingjia;Wang, Meixian;Zhao, Qiaoling;Huang, Jinshan;Tang, Shunming;Shen, Xingjia

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关键词： N6-methyladenosine; Bombyx mori; BmNPV; Resistance

期刊名称：JOURNAL OF ASIA-PACIFIC ENTOMOLOGY （ 影响因子：1.101； 五年影响因子：1.1 ）

ISSN： 1226-8615

年卷期： 2021 年 24 卷 1 期

页码：

收录情况： SCI

摘要： N6-methyladeosine (m(6)A) plays an important role in virus infection and replication. Bombyx mori nuclear polyhedrosis is caused by Bombyx mori nucleopolyhedrovirus (BmNPV) infection. Expression levels of m(6)A-modification-related genes after the infection of BmNPV were detected at first. Then, expression levels of BmNPV nucleocapsid protein gene VP39 and envelope fusion protein gene GP64 after knockdown of METTL3in vitro were quantified to identify the effect of m(6)A modification on BmNPV. BmNPV firstly infects the larval midgut in case of oral infection. Subsequently, to clarify the relationship between m(6)A modification and resistance of the silkworm to BmNPV, we detected the expression levels of m(6)A-modification-related genes invivo before and after infection of BmNPV. The results indicated that low METTL3 level hindered the proliferation of BmNPV to some extent, and silkworm strain with low METTL3 level showed stronger resistance against BmNPV. This study will accumulate new experimental data for elucidating the resistance mechanism of silkworm against BmNPV.

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