FcRn is not the receptor mediating the transfer of serum IgG to colostrum in pigs

文献类型： 外文期刊

第一作者： Ke, Cuncun

作者： Ke, Cuncun;Ma, Yonghe;Wan, Zihui;Feng, Tao;Yu, Dawei;Liu, Xiaojuan;Wang, Haitao;Du, Lijuan;Wang, Xifeng;Li, Kongpan;Yu, Di;Zhang, Ming;Huang, Jinwei;Ren, Liming;Hu, Xiaoxiang;Wu, Sen;Han, Haitang;Zhao, Yaofeng;Ke, Cuncun;Qu, Junwei;Hu, Yanzhong;Pan, Dengke;Du, Minjie;Huang, Linhua;Zhang, Yifu;Cao, Gengsheng

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关键词： FcRn; IgG homeostasis; maternal IgG; transport

期刊名称：IMMUNOLOGY （ 影响因子：5.016； 五年影响因子：4.324 ）

ISSN： 0019-2805

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收录情况： SCI

摘要： In contrast to humans or rabbits, in which maternal IgG is transmitted to offspring prenatally via the placenta or the yolk sac, large domestic animals such as pigs, cows and sheep transmit IgG exclusively through colostrum feeding after delivery. The extremely high IgG content in colostrum is absorbed by newborns via the small intestine. Although it is widely accepted that the neonatal Fc receptor, FcRn, is the receptor mediating IgG transfer across both the placenta and small intestine, it remains unclear whether FcRn also mediates serum IgG transfer across the mammary barrier to colostrum/milk, especially in large domestic animals. In this study, using a FcRn knockout pig model generated with a CRISPR-Cas9-based approach, we clearly demonstrate that FcRn is not responsible for the IgG transfer from serum to colostrum in pigs, although like in other mammals, it is involved in IgG homeostasis and mediates IgG absorption in the small intestine of newborns.

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